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A Prospective Study of Cerebral Ischemia in the Young, Analysis of Pathogenic Determinants
Stroke 24:362-367, Carolei,A.,et al, 1993
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Article Abstract
Women predominated(61%)among patients under 35 years of age,mainly due to the frequency of cerebral ischemia related to oral contraceptive use,while men outnumbered women(60%)among patients over that age because of a higher prevalence of atherothrombotic disease.Potential cerebral embolism of cardiac origin was the presumed cause of stroke in 23.7%,but conventional sources of emboli were found in 7.5%of cases.There was a low prevalence ofd atrial fibrrillation among young patients with cerebral ischemia. Mitral valve prolapse was found in 8.4%,as expected,predominantly(71.4%) among the younger patients.The prevalence of stroke over transient ischemic attack was proportional to the likelihood of cardiac embolism. Acutre alcholhol intoxication was considered a precipitating factor in only three patients.The percentages of cerebral ischemia attributed to atrial dissection(0.3%),oral contra-ceptive use in women(8.1%),migraine(1. 2%),and other associated medical diseases(1.5%)were lower than reported in recent clinical series.Two different groups of pathogenic determinants predominate in younger women and in older men,supporting public health measures aimed at strict medical control of the recognized cerebrovascular risk factors.
 
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cerebral ischemia
cerebrovascular accident
cerebrovascular accident,etiology
cerebrovascular accident,pathophysiology
cerebrovascular accident,prevention of
cerebrovascular accident,young adult
risk factors

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